How does Hyaluronidase Work?
Hyaluronidase works as an enzyme to temporarily break down hyaluronic acid which is found naturally in the body. This makes it easier for injection of fluids to be administered, and effective absorption of the fluids into the skin and tissue.
Hyaluronidases additionally aids the body to reabsorb blood and fluids from the tissues, in the case of a large bruise.
What's in the box?
- Hyaluronidase enzyme (active ingredient)
- 10 amps (1500iu)
What are the benefits of Hyaluronidase?
- Aid in the penetration of fluids during subcutaneous and intramuscular injections
- Hyaluronidase can be directly added to the fluid or solution that is being infected into the skin
- Aids absorption of a subcutaneous infusion, where Hyaluronidase is injected beforehand into the site of injection where the injection is to be administered
- To aid the body to reabsorb fluids or blood in haematomas or extravasation, where Hyaluronidase is mixed with saline or water before being injected at the site of injection
- Breaks down Hyaluronic acid which is present between cells to help them adhesive together. This is a temporary action and helps the quick absorption of fluid injections.
Hyaluronidase are a family of enzymes that catalyse the degradation of hyaluronic acid (HA). Karl Meyer classified these enzymes in 1971 into three distinct groups, a scheme based on the enzyme reaction products. The three main types of hyaluronidases are two classes of eukaryotic endoglycosidase hydrolases and a prokaryotic lyase-type of glycosidase
In humans, there are five functional hyaluronidases: HYAL1, HYAL2, HYAL3, HYAL4 and HYAL5 (also known as SPAM1 or PH-20); plus a pseudogene, HYAL6 (also known as HYALP1). The genes for HYAL1-3 are clustered in chromosome 3, while HYAL4-6 are clustered in chromosome 7. HYAL1 and HYAL2 are the major hyaluronidases in most tissues. GPI-anchored HYAL2 is responsible for cleaving high-molecular weight HA, which is mostly bound to the CD44 receptor. The resulting HA fragments of variable size are then further hydrolized by HYAL1 after being internalized into endo-lysosomes; this generates HA oligosaccharides.
According to their enzymatic mechanism, hyaluronidases are hyaluronoglucosidases (EC 188.8.131.52), i.e. they cleave the (1->4)-linkages between N-acetylglucosamine and glucuronate. The term hyaluronidase may also refer to hyaluronoglucuronidases (EC 184.108.40.206), which cleave (1->3)-linkages. In addition, bacterial hyaluronate lyases (EC220.127.116.11) may also be referred to as hyaluronidases, although this is uncommon.